Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy

Controlled and efficient activation is the crucial aspect of designing an effective prodrug. Herein we demonstrate a proof of concept for a light activatable prodrug with desired organelle specificity. Mertansine, a benzoansamacrolide, is an efficient microtubule-targeting compound that binds at or...

Descripción completa

Detalles Bibliográficos
Autores principales: Tiwari, Rajeshwari, Shinde, Prashant S., Sreedharan, Sreejesh, Dey, Anik Kumar, Vallis, Katherine A., Mhaske, Santosh B., Pramanik, Sumit Kumar, Das, Amitava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179275/
https://www.ncbi.nlm.nih.gov/pubmed/34164035
http://dx.doi.org/10.1039/d0sc06270g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179275/
https://www.ncbi.nlm.nih.gov/pubmed/34164035
http://dx.doi.org/10.1039/d0sc06270g

Ejemplares similares