Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C–N bonds

Bicyclic or tricyclic nitrogen-containing heterocyclic scaffolds were constructed rapidly by intramolecular nucleophilic aromatic substitution of metallated nitriles tethered by a urea linkage to a series of electronically unactivated heterocyclic precursors. The substitution reaction constitutes a...

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Detalles Bibliográficos
Autores principales: Millward, Makenzie J., Ellis, Emily, Ward, John W., Clayden, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179327/
https://www.ncbi.nlm.nih.gov/pubmed/34163972
http://dx.doi.org/10.1039/d0sc06188c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179327/
https://www.ncbi.nlm.nih.gov/pubmed/34163972
http://dx.doi.org/10.1039/d0sc06188c

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