Cargando…

Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β

Pathophysiological shifts in the cerebral levels of sphingolipids in Alzheimer's disease (AD) patients suggest a link between sphingolipid metabolism and the disease pathology. Sphingosine (SP), a structural backbone of sphingolipids, is an amphiphilic molecule that is able to undergo aggregati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yi, Yelim, Lin, Yuxi, Han, Jiyeon, Lee, Hyuck Jin, Park, Nahye, Nam, Geewoo, Park, Young S., Lee, Young-Ho, Lim, Mi Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179336/ https://www.ncbi.nlm.nih.gov/pubmed/34164011 http://dx.doi.org/10.1039/d0sc04366d

Ejemplares similares

Current understanding of metal-dependent amyloid-β aggregation and toxicity
por: Yi, Yelim, et al.
Publicado: (2022)

Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity
por: Du, Zhi, et al.
Publicado: (2023)

Effect of Metals on Kinetic Pathways of Amyloid-β Aggregation
por: Hane, Francis, et al.
Publicado: (2014)

Redox-Active Metal Ions and Amyloid-Degrading Enzymes in Alzheimer’s Disease
por: Kim, Namdoo, et al.
Publicado: (2021)

Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives
por: Korshavn, Kyle J., et al.
Publicado: (2015)

Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring of Amyloid-β Aggregation
por: Kim, Sonam, et al.
Publicado: (2018)

Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease
por: Park, Seongmin, et al.
Publicado: (2023)

Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation
por: Lin, Yuxi, et al.
Publicado: (2022)

Rhodamine-Based Metal Chelator: A Potent Inhibitor of Metal-Catalyzed Amyloid Toxicity
por: Pradhan, Krishnangsu, et al.
Publicado: (2020)

Metal-Complexes Bearing Releasable CO Differently Modulate Amyloid Aggregation
por: La Manna, Sara, et al.
Publicado: (2023)

Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening
por: Lee, Hyuck Jin, et al.
Publicado: (2018)

Correction: Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening
por: Lee, Hyuck Jin, et al.
Publicado: (2019)

Al (III) metal augment thermal aggregation and fibrillation in protein: Role of metal toxicity in neurological diseases
por: Shahnawaz Khan, Mohd, et al.
Publicado: (2020)

Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
por: Cheng, Pin-Nan, et al.
Publicado: (2012)

Taking Charge: Metal Ions Accelerate Amyloid Aggregation in Sequence Variants of α-Synuclein
por: Byrd, Emily J., et al.
Publicado: (2023)

The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity
por: Iannuzzi, Clara, et al.
Publicado: (2015)

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity
por: Porter, Tenielle, et al.
Publicado: (2016)

Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation
por: Kang, Juhye, et al.
Publicado: (2019)

Effect of Sphingosine-1-Phosphate on Intracellular Free Ca(2+) in Cat Esophageal Smooth Muscle Cells
por: Lee, Dong Kyu, et al.
Publicado: (2018)

Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells
por: Lorentzon, Emma, et al.
Publicado: (2021)

Multiple reactivities of flavonoids towards pathological elements in Alzheimer's disease: structure–activity relationship
por: Nam, Geewoo, et al.
Publicado: (2020)

Metal ions and redox balance regulate distinct amyloid-like aggregation pathways of GAPR-1
por: Sheng, Jie, et al.
Publicado: (2019)

Regulation of divalent metal ions to the aggregation and membrane damage of human islet amyloid polypeptide oligomers
por: Wang, Yajie, et al.
Publicado: (2021)

Metals in the Environment: Toxic Metals Removal
por: Atieh, Muataz A., et al.
Publicado: (2017)

The Role of α-sheet in Amyloid Oligomer Aggregation and Toxicity
por: Bi, Timothy M., et al.
Publicado: (2018)

Decreasing amyloid toxicity through an increased rate of aggregation
por: Sonzini, Silvia, et al.
Publicado: (2017)

Oxidation destabilizes toxic amyloid beta peptide aggregation
por: Razzokov, J., et al.
Publicado: (2019)

Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity
por: Khavandi, Marzie, et al.
Publicado: (2023)

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins
por: Cieślik, Magdalena, et al.
Publicado: (2015)

Highly efficient and robust noble-metal free bifunctional water electrolysis catalyst achieved via complementary charge transfer
por: Oh, Nam Khen, et al.
Publicado: (2021)

Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex
por: Wallin, Cecilia, et al.
Publicado: (2020)

Speciation in Metal Toxicity and Metal-Based Therapeutics
por: Templeton, Douglas M.
Publicado: (2015)

Time-restricted feeding reduces monocyte production by controlling hematopoietic stem and progenitor cells in the bone marrow during obesity
por: Kim, Yelim, et al.
Publicado: (2022)

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation
por: Pilkington, Emily H., et al.
Publicado: (2017)

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease
por: Beck, Michael W., et al.
Publicado: (2015)

Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers
por: Koedrith, Preeyaporn, et al.
Publicado: (2011)

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
por: Shin, Soo Jung, et al.
Publicado: (2018)

Amyloids: Regulators of Metal Homeostasis in the Synapse
por: Kawahara, Masahiro, et al.
Publicado: (2020)

Development of Conformational Antibodies to Detect Bcl-xL’s Amyloid Aggregates in Metal-Induced Apoptotic Neuroblastoma Cells
por: Gonneaud, Alexis, et al.
Publicado: (2020)

Vacuum-free solution-based metallization (VSM) of a-IGZO using trimethylaluminium solution
por: Sung, Taehoon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_50p88npiebvhse5o8phevjfnt1