2-Mercaptomethyl-thiazolidines use conserved aromatic–S interactions to achieve broad-range inhibition of metallo-β-lactamases

Infections caused by multidrug resistant (MDR) bacteria are a major public health threat. Carbapenems are among the most potent antimicrobial agents that are commercially available to treat MDR bacteria. Bacterial production of carbapenem-hydrolysing metallo-β-lactamases (MBLs) challenges their safe...

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Detalles Bibliográficos
Autores principales: Rossi, Maria-Agustina, Martinez, Veronica, Hinchliffe, Philip, Mojica, Maria F., Castillo, Valerie, Moreno, Diego M., Smith, Ryan, Spellberg, Brad, Drusano, George L., Banchio, Claudia, Bonomo, Robert A., Spencer, James, Vila, Alejandro J., Mahler, Graciela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179362/
https://www.ncbi.nlm.nih.gov/pubmed/34164056
http://dx.doi.org/10.1039/d0sc05172a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179362/
https://www.ncbi.nlm.nih.gov/pubmed/34164056
http://dx.doi.org/10.1039/d0sc05172a

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