Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a member of the phospholipase D family of enzymes, which catalyzes the removal of both 3′- and 5′-DNA phosphodiester adducts. Importantly, it is capable of reducing the anticancer effects of type I topoisomerase (TOP1) inhibitors by repairing the stalled cov...

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Detalles Bibliográficos
Autores principales: Zhao, Xue Zhi, Kiselev, Evgeny, Lountos, George T., Wang, Wenjie, Tropea, Joseph E., Needle, Danielle, Hilimire, Thomas A., Schneekloth, John S., Waugh, David S., Pommier, Yves, Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179437/
https://www.ncbi.nlm.nih.gov/pubmed/34163656
http://dx.doi.org/10.1039/d0sc05411a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179437/
https://www.ncbi.nlm.nih.gov/pubmed/34163656
http://dx.doi.org/10.1039/d0sc05411a

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