Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrP(C) binding and downstream pathways

Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer's disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tailored library of 971 fluorine containing compoun...

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Detalles Bibliográficos
Autores principales: Grayson, James D., Baumgartner, Matthew P., Santos Souza, Cleide Dos, Dawes, Samuel J., El Idrissi, Imane Ghafir, Louth, Jennifer C., Stimpson, Sasha, Mead, Emma, Dunbar, Charlotte, Wolak, Joanna, Sharman, Gary, Evans, David, Zhuravleva, Anastasia, Roldan, Margarita Segovia, Colabufo, Nicola Antonio, Ning, Ke, Garwood, Claire, Thomas, James A., Partridge, Benjamin M., de la Vega de Leon, Antonio, Gillet, Valerie J., Rauter, Amélia P., Chen, Beining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179515/
https://www.ncbi.nlm.nih.gov/pubmed/34163650
http://dx.doi.org/10.1039/d0sc04769d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179515/
https://www.ncbi.nlm.nih.gov/pubmed/34163650
http://dx.doi.org/10.1039/d0sc04769d

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