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Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Aβo–PrP(C) binding and downstream pathways
Amyloid β oligomers (Aβo) are the main toxic species in Alzheimer's disease, which have been targeted for single drug treatment with very little success. In this work we report a new approach for identifying functional Aβo binding compounds. A tailored library of 971 fluorine containing compoun...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179515/ https://www.ncbi.nlm.nih.gov/pubmed/34163650 http://dx.doi.org/10.1039/d0sc04769d |