Rapid synthesis of pomalidomide-conjugates for the development of protein degrader libraries

Current methods for the preparation of heterobifunctional pomalidomide-conjugates rely on methods that are often low yielding and produce intractable byproducts. Herein we describe our strategy for the reliable and succinct preparation of pomalidomide-linkers which is essential to the formation of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Brownsey, Duncan K., Rowley, Ben C., Gorobets, Evgueni, Gelfand, Benjamin S., Derksen, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179520/
https://www.ncbi.nlm.nih.gov/pubmed/34163717
http://dx.doi.org/10.1039/d0sc05442a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179520/
https://www.ncbi.nlm.nih.gov/pubmed/34163717
http://dx.doi.org/10.1039/d0sc05442a

Ejemplares similares