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Target-templated de novo design of macrocyclic d-/l-peptides: discovery of drug-like inhibitors of PD-1
Peptides are a rapidly growing class of therapeutics with various advantages over traditional small molecules, especially for targeting difficult protein–protein interactions. However, current structure-based methods are largely limited to natural peptides and are not suitable for designing bioactiv...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179567/ https://www.ncbi.nlm.nih.gov/pubmed/34163753 http://dx.doi.org/10.1039/d1sc01031j |