Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester

A new strategy of asymmetric carbonyl catalysis via a chiral Lewis acid-bonded aldehyde has been developed for the direct Mannich/condensation cascade reaction of glycine ester with aromatic aldimines. The co-catalytic system of 2-picolinaldehyde and chiral Yb(III)-N,N′-dioxides was identified to be...

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Detalles Bibliográficos
Autores principales: Zhong, Xia, Zhong, Ziwei, Wu, Zhikun, Ye, Zhen, Feng, Yuxiang, Dong, Shunxi, Liu, Xiaohua, Peng, Qian, Feng, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179594/
https://www.ncbi.nlm.nih.gov/pubmed/34163698
http://dx.doi.org/10.1039/d0sc07052a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179594/
https://www.ncbi.nlm.nih.gov/pubmed/34163698
http://dx.doi.org/10.1039/d0sc07052a

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