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Total synthesis of biselide A

A total synthesis of the marine macrolide biselide A is described that relies on an enantiomerically enriched α-chloroaldehyde as the sole chiral building block. Several strategies to construct the macrocycle are presented including a macrocyclic Reformatsky reaction that ultimately provides access...

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Detalles Bibliográficos
Autores principales: Challa, Venugopal Rao, Kwon, Daniel, Taron, Matthew, Fan, Hope, Kang, Baldip, Wilson, Darryl, Haeckl, F. P. Jake, Keerthisinghe, Sandra, Linington, Roger G., Britton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179649/
https://www.ncbi.nlm.nih.gov/pubmed/34168790
http://dx.doi.org/10.1039/d0sc06223e