CHIP-mediated hyperubiquitylation of tau promotes its self-assembly into the insoluble tau filaments

The tau protein is a highly soluble and natively unfolded protein. Under pathological conditions, tau undergoes multiple post-translational modifications (PTMs) and conformational changes to form insoluble filaments, which are the proteinaceous signatures of tauopathies. To dissect the crosstalk amo...

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Detalles Bibliográficos
Autores principales: Kim, Ji Hyeon, Lee, Jeeyoung, Choi, Won Hoon, Park, Seoyoung, Park, Seo Hyeong, Lee, Jung Hoon, Lim, Sang Min, Mun, Ji Young, Cho, Hyun-Soo, Han, Dohyun, Suh, Young Ho, Lee, Min Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179656/
https://www.ncbi.nlm.nih.gov/pubmed/34168795
http://dx.doi.org/10.1039/d1sc00586c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179656/
https://www.ncbi.nlm.nih.gov/pubmed/34168795
http://dx.doi.org/10.1039/d1sc00586c

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