Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a

PURPOSE: The mechanism underlying curcumin’s protective effect on osteoarthritis (OA) has not been clarified. This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway b...

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Detalles Bibliográficos
Autores principales: Yao, Jiayu, Liu, Xiaotong, Sun, Yingxu, Dong, Xin, Liu, Li, Gu, Hailun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179815/
https://www.ncbi.nlm.nih.gov/pubmed/34103964
http://dx.doi.org/10.2147/JIR.S312139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179815/
https://www.ncbi.nlm.nih.gov/pubmed/34103964
http://dx.doi.org/10.2147/JIR.S312139

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