Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice

OBJECTIVE: Perioperative neurocognitive disorders (PND) are a common complication in the elderly. Histone deacetylases (HDACs) are a class of enzymes that control the acetylation status of intracellular proteins. Thus, we explored whether HDACs trigger the release of high mobility group box 1 (HMGB1...

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Detalles Bibliográficos
Autores principales: Huang, Chen-miao, Cai, Jia-jing, Jin, Shao-wu, Lin, Qi-cheng, Fang, Qian-juan, Nan, Ke, Han, Yuan, Ge, Wen-wei, Liu, Yu, Tao, Yuan-xiang, Cao, Hong, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180279/
https://www.ncbi.nlm.nih.gov/pubmed/34103963
http://dx.doi.org/10.2147/JIR.S304060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180279/
https://www.ncbi.nlm.nih.gov/pubmed/34103963
http://dx.doi.org/10.2147/JIR.S304060

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