Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors “leflunomide” and “teriflunomide” in Covid-19: A narrative review

Dihydroorotate dehydrogenase (DHODH) is rate-limiting enzyme in biosynthesis of pyrimidone which catalyzes the oxidation of dihydro-orotate to orotate. Orotate is utilized in the biosynthesis of uridine-monophosphate. DHODH inhibitors have shown promise as antiviral agent against Cytomegalovirus, Eb...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaur, Hardeep, Sarma, Phulen, Bhattacharyya, Anusuya, Sharma, Saurabh, Chhimpa, Neeraj, Prajapat, Manisha, Prakash, Ajay, Kumar, Subodh, Singh, Ashutosh, Singh, Rahul, Avti, Pramod, Thota, Prasad, Medhi, Bikash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180448/
https://www.ncbi.nlm.nih.gov/pubmed/34111397
http://dx.doi.org/10.1016/j.ejphar.2021.174233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8180448/
https://www.ncbi.nlm.nih.gov/pubmed/34111397
http://dx.doi.org/10.1016/j.ejphar.2021.174233

Ejemplares similares