Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison

Objective: This work aimed to compare the evolution of visual outcomes in Leber hereditary optic neuropathy (LHON) patients treated with intravitreal gene therapy to the spontaneous evolution in prior natural history (NH) studies. Design: A combined analysis of two phase three randomized, double-mas...

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Detalles Bibliográficos
Autores principales: Newman, Nancy J., Yu-Wai-Man, Patrick, Carelli, Valerio, Biousse, Valerie, Moster, Mark L., Vignal-Clermont, Catherine, Sergott, Robert C., Klopstock, Thomas, Sadun, Alfredo A., Girmens, Jean-François, La Morgia, Chiara, DeBusk, Adam A., Jurkute, Neringa, Priglinger, Claudia, Karanjia, Rustum, Josse, Constant, Salzmann, Julie, Montestruc, François, Roux, Michel, Taiel, Magali, Sahel, José-Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181419/
https://www.ncbi.nlm.nih.gov/pubmed/34108929
http://dx.doi.org/10.3389/fneur.2021.662838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181419/
https://www.ncbi.nlm.nih.gov/pubmed/34108929
http://dx.doi.org/10.3389/fneur.2021.662838

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