Anti-HSP47 siRNA lipid nanoparticle ND-L02-s0201 reverses interstitial pulmonary fibrosis in preclinical rat models

ND-L02-s0201 is a lipid nanoparticle encapsulating an siRNA which inhibits expression of heat shock protein 47 (HSP47), a collagen-specific chaperone. Accumulated evidence demonstrates a close association between increased level of HSP47 and excessive accumulation of collagen in fibrotic diseases. O...

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Detalles Bibliográficos
Autores principales: Liu, Yun, Liu, Jian, Quimbo, Alistair, Xia, Fengcheng, Yao, Jiping, Clamme, Jean-Pierre, Zabludoff, Sonya, Zhang, Jun, Ying, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181707/
https://www.ncbi.nlm.nih.gov/pubmed/34109242
http://dx.doi.org/10.1183/23120541.00733-2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181707/
https://www.ncbi.nlm.nih.gov/pubmed/34109242
http://dx.doi.org/10.1183/23120541.00733-2020

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