Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies

A series of novel pyran-linked phthalazinone-pyrazole hybrids were designed and synthesized by a facile one-pot three-component reaction employing substituted phthalazinone, 1H-pyrazole-5-carbaldehyde, and active methylene compounds. Optimization studies led to the identification of L-proline and et...

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Detalles Bibliográficos
Autores principales: Malik, M. Shaheer, Asghar, Basim H., Syed, Riyaz, Alsantali, Reem I., Morad, Moataz, Altass, Hatem M., Moussa, Ziad, Althagafi, Ismail I., Jassas, Rabab S., Ahmed, Saleh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181751/
https://www.ncbi.nlm.nih.gov/pubmed/34109154
http://dx.doi.org/10.3389/fchem.2021.666573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181751/
https://www.ncbi.nlm.nih.gov/pubmed/34109154
http://dx.doi.org/10.3389/fchem.2021.666573

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