KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance

KDM5A and KDM5B histone-demethylases are overexpressed in many cancers and have been involved in drug tolerance. Here, we describe that KDM5A, together with KDM5B, contribute to replication stress (RS) response and tolerance. First, they positively regulate RRM2, the regulatory subunit of ribonucleo...

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Detalles Bibliográficos
Autores principales: Gaillard, Solenne, Charasson, Virginie, Ribeyre, Cyril, Salifou, Kader, Pillaire, Marie-Jeanne, Hoffmann, Jean-Sebastien, Constantinou, Angelos, Trouche, Didier, Vandromme, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181900/
https://www.ncbi.nlm.nih.gov/pubmed/34184733
http://dx.doi.org/10.1242/bio.057729

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181900/
https://www.ncbi.nlm.nih.gov/pubmed/34184733
http://dx.doi.org/10.1242/bio.057729

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