A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants

Downstream processing of mAb charge variants is difficult owing to their similar molecular structures and surface charge properties. This study aimed to apply a novel twin‐column continuous chromatography (called N‐rich mode) to separate and enrich acidic variants of an IgG1 mAb. Besides, a comparis...

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Detalles Bibliográficos
Autores principales: Jing, Shu‐Ying, Shi, Ce, Leong, Hui Yi, Yuan, Jun‐Jie, Gao, Dong, Wang, Hai‐Bin, Yao, Shan‐Jing, Lin, Dong‐Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182273/
https://www.ncbi.nlm.nih.gov/pubmed/34140849
http://dx.doi.org/10.1002/elsc.202000094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182273/
https://www.ncbi.nlm.nih.gov/pubmed/34140849
http://dx.doi.org/10.1002/elsc.202000094

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