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A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants
Downstream processing of mAb charge variants is difficult owing to their similar molecular structures and surface charge properties. This study aimed to apply a novel twin‐column continuous chromatography (called N‐rich mode) to separate and enrich acidic variants of an IgG1 mAb. Besides, a comparis...
Autores principales: | Jing, Shu‐Ying, Shi, Ce, Leong, Hui Yi, Yuan, Jun‐Jie, Gao, Dong, Wang, Hai‐Bin, Yao, Shan‐Jing, Lin, Dong‐Qiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182273/ https://www.ncbi.nlm.nih.gov/pubmed/34140849 http://dx.doi.org/10.1002/elsc.202000094 |
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