Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication

BACKGROUND: Coronavirus (CoV) nonstructural protein 14 (nsp14) has exoribonuclease (ExoN) activity, responsible for proofreading and contributing to replication fidelity. It has been reported that CoVs exhibit variable sensitivity to nsp14-ExoN deficiency. Betacoronavirus murine hepatitis virus (MHV...

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Detalles Bibliográficos
Autores principales: Niu, Xiaoyu, Kong, Fanzhi, Hou, Yixuan J., Wang, Qiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182996/
https://www.ncbi.nlm.nih.gov/pubmed/34099051
http://dx.doi.org/10.1186/s13578-021-00598-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182996/
https://www.ncbi.nlm.nih.gov/pubmed/34099051
http://dx.doi.org/10.1186/s13578-021-00598-1

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