α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanis...

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Detalles Bibliográficos
Autores principales: Delaidelli, Alberto, Richner, Mette, Jiang, Lixiang, van der Laan, Amelia, Bergholdt Jul Christiansen, Ida, Ferreira, Nelson, Nyengaard, Jens R., Vægter, Christian B., Jensen, Poul H., Mackenzie, Ian R., Sorensen, Poul H., Jan, Asad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183088/
https://www.ncbi.nlm.nih.gov/pubmed/34092244
http://dx.doi.org/10.1186/s40478-021-01209-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183088/
https://www.ncbi.nlm.nih.gov/pubmed/34092244
http://dx.doi.org/10.1186/s40478-021-01209-3

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