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CryoDRGN: Reconstruction of heterogeneous cryo-EM structures using neural networks
Cryo-EM single-particle analysis has proven powerful in determining the structures of rigid macromolecules. However, many imaged protein complexes exhibit complex conformational and compositional heterogeneity that pose a major challenge to existing 3D reconstruction methods. Here, we present cryoDR...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183613/ https://www.ncbi.nlm.nih.gov/pubmed/33542510 http://dx.doi.org/10.1038/s41592-020-01049-4 |