Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure model

BACKGROUND: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca(2+) leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2...

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Detalles Bibliográficos
Autores principales: Nofi, Colleen, Zhang, Kuo, Tang, Yi-Da, Li, Ying, Migirov, Allan, Ojamaa, Kaie, Gerdes, A. Martin, Zhang, Youhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Experimental
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183840/
https://www.ncbi.nlm.nih.gov/pubmed/34113867
http://dx.doi.org/10.1016/j.hroo.2020.03.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183840/
https://www.ncbi.nlm.nih.gov/pubmed/34113867
http://dx.doi.org/10.1016/j.hroo.2020.03.004

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