Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

Glucocorticoids are key regulators of glucose homeostasis and pancreatic islet function, but the gene regulatory programs driving responses to glucocorticoid signaling in islets and the contribution of these programs to diabetes risk are unknown. In this study we used ATAC-seq and RNA-seq to map chr...

Descripción completa

Detalles Bibliográficos
Autores principales: Aylward, Anthony, Okino, Mei-Lin, Benaglio, Paola, Chiou, Joshua, Beebe, Elisha, Padilla, Jose Andres, Diep, Sharlene, Gaulton, Kyle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183998/
https://www.ncbi.nlm.nih.gov/pubmed/33983929
http://dx.doi.org/10.1371/journal.pgen.1009531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183998/
https://www.ncbi.nlm.nih.gov/pubmed/33983929
http://dx.doi.org/10.1371/journal.pgen.1009531

Ejemplares similares