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Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling

We sought to understand how perturbation of signaling pathways and their targets generates variable phenotypes. In humans, GATA3 associates with highly variable defects, such as HDR syndrome, microsomia and choanal atresia. We previously characterized a zebrafish point mutation in gata3 with highly...

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Detalles Bibliográficos
Autores principales: Swartz, Mary E., Lovely, C. Ben, Eberhart, Johann K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184005/
https://www.ncbi.nlm.nih.gov/pubmed/34033651
http://dx.doi.org/10.1371/journal.pgen.1009579