Pore mutation N617D in the skeletal muscle DHPR blocks Ca(2+) influx due to atypical high-affinity Ca(2+) binding

Skeletal muscle excitation-contraction (EC) coupling roots in Ca(2+)-influx-independent inter-channel signaling between the sarcolemmal dihydropyridine receptor (DHPR) and the ryanodine receptor (RyR1) in the sarcoplasmic reticulum. Although DHPR Ca(2+) influx is irrelevant for EC coupling, its puta...

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Detalles Bibliográficos
Autores principales: Dayal, Anamika, Fernández-Quintero, Monica L, Liedl, Klaus R, Grabner, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184209/
https://www.ncbi.nlm.nih.gov/pubmed/34061024
http://dx.doi.org/10.7554/eLife.63435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184209/
https://www.ncbi.nlm.nih.gov/pubmed/34061024
http://dx.doi.org/10.7554/eLife.63435

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