Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp

BACKGROUND: Methotrexate (MTX) is an important anticancer agent and immunosuppressant with a narrow therapeutic window. Wuzhi capsule (WZC) is an extract of Schisandra which is widely used to treat liver diseases. Co-administration of MTX and WZC is common in the clinical setting, but research on th...

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Detalles Bibliográficos
Autores principales: Fu, Ran, Wang, Xiao-Nan, Guo, Cai-Hui, Li, Ying, Ding, Cong-Yang, Li, Ya-Jing, Dong, Zhan-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184478/
https://www.ncbi.nlm.nih.gov/pubmed/34164479
http://dx.doi.org/10.21037/atm-21-1303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184478/
https://www.ncbi.nlm.nih.gov/pubmed/34164479
http://dx.doi.org/10.21037/atm-21-1303

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