Cargando…

Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp

BACKGROUND: Methotrexate (MTX) is an important anticancer agent and immunosuppressant with a narrow therapeutic window. Wuzhi capsule (WZC) is an extract of Schisandra which is widely used to treat liver diseases. Co-administration of MTX and WZC is common in the clinical setting, but research on th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fu, Ran, Wang, Xiao-Nan, Guo, Cai-Hui, Li, Ying, Ding, Cong-Yang, Li, Ya-Jing, Dong, Zhan-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184478/ https://www.ncbi.nlm.nih.gov/pubmed/34164479 http://dx.doi.org/10.21037/atm-21-1303

Ejemplares similares

Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients
por: Yan, Lin, et al.
Publicado: (2019)

The pharmacokinetic study of tacrolimus and Wuzhi capsule in Chinese liver transplant patients
por: Qu, Jinlong, et al.
Publicado: (2022)

Clinical Evaluation of the Efficacy and Safety of Co-Administration of Wuzhi Capsule and Tacrolimus in Adult Chinese Patients with Myasthenia Gravis
por: Peng, Yuyao, et al.
Publicado: (2021)

Clinical observation on the effect of Wuzhi soft capsule on FK506 concentration in membranous nephropathy patients
por: Zhang, Zhu, et al.
Publicado: (2019)

Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis
por: Chen, Lizhi, et al.
Publicado: (2021)

Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2
por: Liao, Xiao-ying, et al.
Publicado: (2019)

Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
por: Bi, Huichang, et al.
Publicado: (2013)

Schisandra sphenanthera extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice
por: Zeng, Xuezhen, et al.
Publicado: (2017)

Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity
por: Hu, S, et al.
Publicado: (2017)

Processing of oat: the impact on oat's cholesterol lowering effect
por: Grundy, Myriam M.-L., et al.
Publicado: (2018)

Absorption and Elimination of Oat Avenanthramides in Humans after Acute Consumption of Oat Cookies
por: Zhang, Tianou, et al.
Publicado: (2017)

Genome resequencing reveals independent domestication and breeding improvement of naked oat
por: Nan, Jinsheng, et al.
Publicado: (2023)

OATE Conference
por: Araki, Huzihiro, et al.
Publicado: (1985)

Wild Oats
Publicado: (1899)

Oat Meal
Publicado: (1891)

Oat Meal
Publicado: (1874)

To Be Oats or Not to Be? An Update on the Ongoing Debate on Oats for Patients With Celiac Disease
por: Spector Cohen, Inna, et al.
Publicado: (2019)

PSII Activity Was Inhibited at Flowering Stage with Developing Black Bracts of Oat
por: Liu, Bei, et al.
Publicado: (2021)

Increasing dietary oat fibre decreases the permeability of intestinal mucus
por: Mackie, Alan, et al.
Publicado: (2016)

CAN a P-gp modulator assist in the control of methotrexate concentrations in the rat brain? −inhibitory effects of rhodamine 123, a specific substrate for P-gp, on methotrexate excretion from the rat brain and its optimal route of administration
por: OGUSHI, Naofumi, et al.
Publicado: (2016)

Traditional Chinese medicine Biqi capsule compared with leflunomide in combination with methotrexate in patients with rheumatoid arthritis: a randomized controlled trial
por: Wang, Zhang, et al.
Publicado: (2020)

Commentary: To Be Oats or Not to Be? An Update on the Ongoing Debate on Oats for Patients With Celiac Disease
por: Fritz, Ronald D., et al.
Publicado: (2020)

Narrative Review on the Effects of Oat and Sprouted Oat Components on Blood Pressure
por: Liska, DeAnn J., et al.
Publicado: (2022)

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway
por: Morsy, Mohamed A., et al.
Publicado: (2022)

Sowing Wild Oats
Publicado: (1914)

Efficacy of Bi Qi Capsules in combination with methotrexate in the treatment of rheumatoid arthritis: A protocol of double-blind randomized controlled trial
por: Ding, Weizhong, et al.
Publicado: (2021)

Survey of T-2 and HT-2 toxins by LC–MS/MS in oats and oat products from European oat mills in 2005–2009
por: Pettersson, Hans, et al.
Publicado: (2011)

The Biosynthetic Pathway of Major Avenanthramides in Oat
por: Li, Zhiyong, et al.
Publicado: (2019)

Solvent Retention Capacities of Oat Flour
por: Niu, Qianwen, et al.
Publicado: (2017)

Inhibition of miR-16 enhances the sensitivity of fibroblast-like synovial cells to methotrexate by restraining MDR1/P-gp expression via NF-κB pathway
por: Wang, Jing, et al.
Publicado: (2019)

Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease
por: Comino, Isabel, et al.
Publicado: (2011)

The Genetic Architecture of Milling Quality in Spring Oat Lines of the Collaborative Oat Research Enterprise
por: Esvelt Klos, Kathy, et al.
Publicado: (2021)

Unusual Flavones from Primula macrocalyx as Inhibitors of OAT1 and OAT3 and as Antifungal Agents against Candida rugosa
por: Li, Xue, et al.
Publicado: (2019)

Novel morphologies of poly(allyamine hydrochloride)–methotrexate nanoassemblies for methotrexate delivery
por: Wang, Wei-Yuan, et al.
Publicado: (2018)

Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice
por: Yu, Wen-Hao, et al.
Publicado: (2015)

Oats Intolerance in Celiac Disease
Publicado: (2004)

Decoction of Oats as a Diuretic
Publicado: (1855)

Oat Plant Amyloids for Sustainable Functional Materials
por: Zhou, Jiangtao, et al.
Publicado: (2021)

Inclusion of Oat in Feeding Can Increase the Potential Probiotic Bifidobacteria in Sow Milk
por: Gyawali, Rabin, et al.
Publicado: (2015)

Coordinate regulation of systemic and kidney tryptophan metabolism by the drug transporters OAT1 and OAT3
por: Granados, Jeffry C., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9glro5p13463fh5hkqbgi9hi3j