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Wuzhi capsule increased systemic exposure to methotrexate by inhibiting the expression of OAT1/3 and P-gp
BACKGROUND: Methotrexate (MTX) is an important anticancer agent and immunosuppressant with a narrow therapeutic window. Wuzhi capsule (WZC) is an extract of Schisandra which is widely used to treat liver diseases. Co-administration of MTX and WZC is common in the clinical setting, but research on th...
Autores principales: | Fu, Ran, Wang, Xiao-Nan, Guo, Cai-Hui, Li, Ying, Ding, Cong-Yang, Li, Ya-Jing, Dong, Zhan-Jun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184478/ https://www.ncbi.nlm.nih.gov/pubmed/34164479 http://dx.doi.org/10.21037/atm-21-1303 |
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