ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

DNA double-strand break (DSB) repair by homologous recombination (HR) is essential for ensuring genome stability. Abnormal spindle-like microcephaly-associated (ASPM) gene encodes a spindle protein that is commonly implicated in primary microcephaly. We found that ASPM is recruited to sites of DNA d...

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Detalles Bibliográficos
Autores principales: Xu, Shibin, Wu, Xingxuan, Wang, Peipei, Cao, Sheng-Li, Peng, Bin, Xu, Xingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
https://www.ncbi.nlm.nih.gov/pubmed/34142045
http://dx.doi.org/10.1016/j.isci.2021.102534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184511/
https://www.ncbi.nlm.nih.gov/pubmed/34142045
http://dx.doi.org/10.1016/j.isci.2021.102534

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