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Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant

There is an unmet need for new influenza vaccine strategies that compensate for impaired vaccine responses in elderly individuals. Here, we evaluated the effectiveness of a single-stranded RNA (ssRNA) as an adjuvant to enhance the efficacy of inactivated influenza vaccine (IIV) in mouse models. Immu...

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Detalles Bibliográficos
Autores principales: Bang, Yoo-Jin, Hong, So-Hee, Park, Hyo-Jung, Kwak, Hye Won, Lee, Yu-Sun, Kim, Jae-Yong, Park, Hyeong-Jun, Bae, Seo-Hyeon, Kim, Hye-Jung, Kim, Yun-Hee, Ko, Hae Li, Park, Sang-In, Kim, Hun, Park, Gyeongjoo, Park, Man-Seong, Chang, Jun, Nam, Jae-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184738/
https://www.ncbi.nlm.nih.gov/pubmed/34099809
http://dx.doi.org/10.1038/s41598-021-91445-3