Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative diseases with overlapping clinical features and the pathological hallmark of cytoplasmic deposits of misfolded proteins. The most frequent cause of familial forms of these diseases is a hexanucleotide repeat expansio...

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Detalles Bibliográficos
Autores principales: Babu, Maria, Favretto, Filippo, de Opakua, Alain Ibáñez, Rankovic, Marija, Becker, Stefan, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184751/
https://www.ncbi.nlm.nih.gov/pubmed/34099711
http://dx.doi.org/10.1038/s41467-021-23691-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184751/
https://www.ncbi.nlm.nih.gov/pubmed/34099711
http://dx.doi.org/10.1038/s41467-021-23691-y

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