Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics

Characterizing the human leukocyte antigen (HLA) bound ligandome by mass spectrometry (MS) holds great promise for developing vaccines and drugs for immune-oncology. Still, the identification of non-tryptic peptides presents substantial computational challenges. To address these, we synthesized and...

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Detalles Bibliográficos
Autores principales: Wilhelm, Mathias, Zolg, Daniel P., Graber, Michael, Gessulat, Siegfried, Schmidt, Tobias, Schnatbaum, Karsten, Schwencke-Westphal, Celina, Seifert, Philipp, de Andrade Krätzig, Niklas, Zerweck, Johannes, Knaute, Tobias, Bräunlein, Eva, Samaras, Patroklos, Lautenbacher, Ludwig, Klaeger, Susan, Wenschuh, Holger, Rad, Roland, Delanghe, Bernard, Huhmer, Andreas, Carr, Steven A., Clauser, Karl R., Krackhardt, Angela M., Reimer, Ulf, Kuster, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184761/
https://www.ncbi.nlm.nih.gov/pubmed/34099720
http://dx.doi.org/10.1038/s41467-021-23713-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184761/
https://www.ncbi.nlm.nih.gov/pubmed/34099720
http://dx.doi.org/10.1038/s41467-021-23713-9

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