Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

APOE and Trem2 are major genetic risk factors for Alzheimer’s disease (AD), but how they affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific phospholipid signature with correlation between human APOEε3/3 and APOEε4/4 AD brain and lipoproteins from astrocyte condi...

Descripción completa

Detalles Bibliográficos
Autores principales: Fitz, Nicholas F., Nam, Kyong Nyon, Wolfe, Cody M., Letronne, Florent, Playso, Brittany E., Iordanova, Bistra E., Kozai, Takashi D. Y., Biedrzycki, Richard J., Kagan, Valerian E., Tyurina, Yulia Y., Han, Xianlin, Lefterov, Iliya, Koldamova, Radosveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184801/
https://www.ncbi.nlm.nih.gov/pubmed/34099706
http://dx.doi.org/10.1038/s41467-021-23762-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184801/
https://www.ncbi.nlm.nih.gov/pubmed/34099706
http://dx.doi.org/10.1038/s41467-021-23762-0

Ejemplares similares