A small molecule inhibitor of Nox2 and Nox4 improves contractile function after ischemia–reperfusion in the mouse heart

The NADPH oxidase enzymes Nox2 and 4, are important generators of Reactive oxygen species (ROS). These enzymes are abundantly expressed in cardiomyocytes and have been implicated in ischemia–reperfusion injury. Previous attempts with full inhibition of their activity using genetically modified anima...

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Detalles Bibliográficos
Autores principales: Szekeres, Ferenc L. M., Walum, Erik, Wikström, Per, Arner, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184855/
https://www.ncbi.nlm.nih.gov/pubmed/34099836
http://dx.doi.org/10.1038/s41598-021-91575-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184855/
https://www.ncbi.nlm.nih.gov/pubmed/34099836
http://dx.doi.org/10.1038/s41598-021-91575-8

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