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Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation

Keratinocyte cornification and epidermal barrier formation are tightly controlled processes, which require complete degradation of intracellular organelles, including removal of keratinocyte nuclei. Keratinocyte nuclear destruction requires Akt1-dependent phosphorylation and degradation of the nucle...

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Detalles Bibliográficos
Autores principales: Rogerson, Clare, Wotherspoon, Duncan J., Tommasi, Cristina, Button, Robert W., O’Shaughnessy, Ryan F. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184862/
https://www.ncbi.nlm.nih.gov/pubmed/33462407
http://dx.doi.org/10.1038/s41418-020-00712-9