Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice

Animal models of human diseases are classically fed purified diets that contain casein as the unique protein source. We show that provision of a mixed protein source mirroring that found in the western diet exacerbates diet-induced obesity and insulin resistance by potentiating hepatic mTORC1/S6K1 s...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Béatrice S.-Y., Daniel, Noëmie, Houde, Vanessa P., Ouellette, Adia, Marcotte, Bruno, Varin, Thibault V., Vors, Cécile, Feutry, Perrine, Ilkayeva, Olga, Ståhlman, Marcus, St-Pierre, Philippe, Bäckhed, Fredrik, Tremblay, Angelo, White, Phillip J., Marette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184893/
https://www.ncbi.nlm.nih.gov/pubmed/34099716
http://dx.doi.org/10.1038/s41467-021-23782-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184893/
https://www.ncbi.nlm.nih.gov/pubmed/34099716
http://dx.doi.org/10.1038/s41467-021-23782-w

Ejemplares similares