A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

Impaired wound healing and ulcer complications are a leading cause of death in diabetic patients. In this study, we report the design and synthesis of a cyclometalated iridium(III) metal complex 1a as a stabilizer of hypoxia-inducible factor-1α (HIF-1α). In vitro biophysical and cellular analyses de...

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Detalles Bibliográficos
Autores principales: Li, Guodong, Ko, Chung-Nga, Li, Dan, Yang, Chao, Wang, Wanhe, Yang, Guan-Jun, Di Primo, Carmelo, Wong, Vincent Kam Wai, Xiang, Yaozu, Lin, Ligen, Ma, Dik-Lung, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184911/
https://www.ncbi.nlm.nih.gov/pubmed/34099651
http://dx.doi.org/10.1038/s41467-021-23448-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184911/
https://www.ncbi.nlm.nih.gov/pubmed/34099651
http://dx.doi.org/10.1038/s41467-021-23448-7

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