Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response

The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that the DNA-PK-p53 cascade induced primary cilia formation (ciliogenesis), thus maintaining the DN...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Ting-Yu, Huang, Bu-Miin, Tang, Tang K., Chao, Yu-Ying, Xiao, Xiao-Yi, Lee, Pei-Rong, Yang, Li-Yun, Wang, Chia-Yih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184926/
https://www.ncbi.nlm.nih.gov/pubmed/33462409
http://dx.doi.org/10.1038/s41418-020-00713-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184926/
https://www.ncbi.nlm.nih.gov/pubmed/33462409
http://dx.doi.org/10.1038/s41418-020-00713-8

Ejemplares similares