Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Diabetes can be caused by an insufficiency in β-cell mass. Here, we performed a genetic screen in a zebrafish model of β-cell loss to identify pathways promoting β-cell regeneration. We found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated β-cell differ...

Descripción completa

Detalles Bibliográficos
Autores principales: Karampelias, Christos, Rezanejad, Habib, Rosko, Mandy, Duan, Likun, Lu, Jing, Pazzagli, Laura, Bertolino, Philippe, Cesta, Carolyn E., Liu, Xiaojing, Korbutt, Gregory S., Andersson, Olov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184927/
https://www.ncbi.nlm.nih.gov/pubmed/34099692
http://dx.doi.org/10.1038/s41467-021-23673-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184927/
https://www.ncbi.nlm.nih.gov/pubmed/34099692
http://dx.doi.org/10.1038/s41467-021-23673-0

Ejemplares similares