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Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Diabetes can be caused by an insufficiency in β-cell mass. Here, we performed a genetic screen in a zebrafish model of β-cell loss to identify pathways promoting β-cell regeneration. We found that both folate receptor 1 (folr1) overexpression and treatment with folinic acid, stimulated β-cell differ...

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Detalles Bibliográficos
Autores principales:	Karampelias, Christos, Rezanejad, Habib, Rosko, Mandy, Duan, Likun, Lu, Jing, Pazzagli, Laura, Bertolino, Philippe, Cesta, Carolyn E., Liu, Xiaojing, Korbutt, Gregory S., Andersson, Olov
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184927/ https://www.ncbi.nlm.nih.gov/pubmed/34099692 http://dx.doi.org/10.1038/s41467-021-23673-0

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