A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids

Excess glucocorticoids (GCs) with either endogenous or exogenous origins deteriorate skin barrier function. GCs bind to mineralocorticoid and GC receptors (MRs and GRs) in normal human epidermal keratinocytes (NHEKs). Inappropriate MR activation by GCs mediates various GC-induced cutaneous adverse e...

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Detalles Bibliográficos
Autores principales: Lee, Hanil, Choi, Eun-Jeong, Kim, Eun Jung, Son, Eui Dong, Kim, Hyoung-June, Park, Won-Seok, Kang, Young-Gyu, Shin, Kyong-Oh, Park, Kyungho, Kim, Jin-Chul, Kim, Su-Nam, Choi, Eung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184959/
https://www.ncbi.nlm.nih.gov/pubmed/34099793
http://dx.doi.org/10.1038/s41598-021-91450-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184959/
https://www.ncbi.nlm.nih.gov/pubmed/34099793
http://dx.doi.org/10.1038/s41598-021-91450-6

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