A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation

Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA from virus or self-DNA from mitochondria/nuclei. In response to emergence of such DNAs in the cytosol, STING translocates from the endoplasmic reticulum to the Golgi, and activates TANK-bi...

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Detalles Bibliográficos
Autores principales: Takahashi, Kanoko, Niki, Takahiro, Ogawa, Emari, Fumika, Kiku, Nishioka, Yu, Sawa, Masaaki, Arai, Hiroyuki, Mukai, Kojiro, Taguchi, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184970/
https://www.ncbi.nlm.nih.gov/pubmed/34099821
http://dx.doi.org/10.1038/s41598-021-91562-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184970/
https://www.ncbi.nlm.nih.gov/pubmed/34099821
http://dx.doi.org/10.1038/s41598-021-91562-z

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