Replicate sequencing libraries are important for quantification of allelic imbalance

A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and sequence only one library per RNA sample. We present theoretical and ex...

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Detalles Bibliográficos
Autores principales: Mendelevich, Asia, Vinogradova, Svetlana, Gupta, Saumya, Mironov, Andrey A., Sunyaev, Shamil R., Gimelbrant, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184992/
https://www.ncbi.nlm.nih.gov/pubmed/34099647
http://dx.doi.org/10.1038/s41467-021-23544-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184992/
https://www.ncbi.nlm.nih.gov/pubmed/34099647
http://dx.doi.org/10.1038/s41467-021-23544-8

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