Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU

In the adult human brain, six isoforms of the microtubule-associated protein TAU are expressed, which result from alternative splicing of exons 2, 3, and 10 of the MAPT gene. These isoforms differ in the number of N-terminal inserts (0N, 1N, 2N) and C-terminal repeat domains (3R or 4R) and are diffe...

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Detalles Bibliográficos
Autores principales: Bachmann, Sarah, Bell, Michael, Klimek, Jennifer, Zempel, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185039/
https://www.ncbi.nlm.nih.gov/pubmed/34113229
http://dx.doi.org/10.3389/fnins.2021.643115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185039/
https://www.ncbi.nlm.nih.gov/pubmed/34113229
http://dx.doi.org/10.3389/fnins.2021.643115

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