Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

Kdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein we found that myeloid-specific knockout of Kdm2a (LysM-Cre-Kdm2a(f/f), Kdm2a(−/−)) promoted macrophage M2 program by reprograming metabolic homeostasi...

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Detalles Bibliográficos
Autores principales: Chen, Longmin, Zhang, Jing, Zou, Yuan, Wang, Faxi, Li, Jingyi, Sun, Fei, Luo, Xi, Zhang, Meng, Guo, Yanchao, Yu, Qilin, Yang, Ping, Zhou, Qing, Chen, Zhishui, Zhang, Huilan, Gong, Quan, Zhao, Jiajun, Eizirik, Decio L., Zhou, Zhiguang, Xiong, Fei, Zhang, Shu, Wang, Cong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185071/
https://www.ncbi.nlm.nih.gov/pubmed/33462408
http://dx.doi.org/10.1038/s41418-020-00714-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185071/
https://www.ncbi.nlm.nih.gov/pubmed/33462408
http://dx.doi.org/10.1038/s41418-020-00714-7

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