Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo

In the liver, the bile canaliculi of hepatocytes are connected to intrahepatic bile ducts lined with cholangiocytes, which remove cytotoxic bile from the liver tissue. Although liver organoids have been reported, it is not clear whether the functional connection between hepatocytes and cholangiocyte...

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Detalles Bibliográficos
Autores principales: Tanimizu, Naoki, Ichinohe, Norihisa, Sasaki, Yasushi, Itoh, Tohru, Sudo, Ryo, Yamaguchi, Tomoko, Katsuda, Takeshi, Ninomiya, Takafumi, Tokino, Takashi, Ochiya, Takahiro, Miyajima, Atsushi, Mitaka, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185093/
https://www.ncbi.nlm.nih.gov/pubmed/34099675
http://dx.doi.org/10.1038/s41467-021-23575-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185093/
https://www.ncbi.nlm.nih.gov/pubmed/34099675
http://dx.doi.org/10.1038/s41467-021-23575-1

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