TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice

The mechanisms regulating myelin repair in the adult central nervous system (CNS) are unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven-Translocation (TET) enzyme TET1, as necessary for myelin repair in young adults and defective in old mice. Constitutive and inducible o...

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Detalles Bibliográficos
Autores principales: Moyon, Sarah, Frawley, Rebecca, Marechal, Damien, Huang, Dennis, Marshall-Phelps, Katy L. H., Kegel, Linde, Bøstrand, Sunniva M. K., Sadowski, Boguslawa, Jiang, Yong-Hui, Lyons, David A., Möbius, Wiebke, Casaccia, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185117/
https://www.ncbi.nlm.nih.gov/pubmed/34099715
http://dx.doi.org/10.1038/s41467-021-23735-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185117/
https://www.ncbi.nlm.nih.gov/pubmed/34099715
http://dx.doi.org/10.1038/s41467-021-23735-3

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