Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding affinity to the ACE2 receptor and confer antibody escape...

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Detalles Bibliográficos
Autores principales: Meng, Bo, Kemp, Steven A., Papa, Guido, Datir, Rawlings, Ferreira, Isabella A.T.M., Marelli, Sara, Harvey, William T., Lytras, Spyros, Mohamed, Ahmed, Gallo, Giulia, Thakur, Nazia, Collier, Dami A., Mlcochova, Petra, Duncan, Lidia M., Carabelli, Alessandro M., Kenyon, Julia C., Lever, Andrew M., De Marco, Anna, Saliba, Christian, Culap, Katja, Cameroni, Elisabetta, Matheson, Nicholas J., Piccoli, Luca, Corti, Davide, James, Leo C., Robertson, David L., Bailey, Dalan, Gupta, Ravindra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185188/
https://www.ncbi.nlm.nih.gov/pubmed/34166617
http://dx.doi.org/10.1016/j.celrep.2021.109292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185188/
https://www.ncbi.nlm.nih.gov/pubmed/34166617
http://dx.doi.org/10.1016/j.celrep.2021.109292

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